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Best over the counter substitute for viagra. And, just like that, the anti-aging industry was born. The industry was a mixed bag, but the most popular was hormone replacement therapy (HRT) industry, which used to market a variety of things like DHEA and estrogen. HRT was first developed and marketed by a professor named Abraham Walden. In the early 1950s, he was working at the University of Tennessee and decided this was a good opportunity to create company that would be able to sell this new drug of the future. He got funds, set up shop, and by 1958, he had a successful patent for new treatment called DES. DES was a synthetic version of estradiol, female hormone that's usually produced by the ovaries. It's essential for normal female development and maintenance. It works by inhibiting the enzyme aromatase. That means estrogen it produces is not made in the body. But DES has other unusual properties. It's not absorbed by the body, so it's easily transported through the blood and into liver kidneys. It's also not linked to most adverse effects of estrogen. So, it had all the advantages of a synthetic hormone without the bad stuff that gets in the body and wreaks havoc. It was just what people wanted to use. And then, suddenly, in 1965, there was a report that DES causing kidney problems in lab rats. After many studies, that report was retracted and the animal studies were done again. But the results were still same – DES caused problems. By the late 1970s, scientists had begun to test DES's side effects and the results were horrific. According to the U.S. National Institutes viagra us generic of Health, DES caused birth defects and other reproductive problems in animals. Even studies showing DES's efficacy were found to have major flaws in design and execution. And, the studies that were done had been in the most unethical ways. For instance, researchers were told to alter the design of their studies to see if they could get consistent results. When experiments were done, the results often not even close. If DES was approved without an adequate study, and there was a chance it would cause harm, the FDA be liable for risks. So, in the end, DES was never approved for use in humans and never took off elsewhere in the world. By the late 1980s, most people were convinced that DES was a dangerous thing to be injected into women. And, that's when the birth control industry tried to rebrand it as something else – to make it more appealing. So, in the 1990s, they came up with a slightly different version of DES. It's called raloxifene (or just ralox), and it's supposed to protect women from estrogen. The problem is, it turns out that ralox also causes serious birth defects and it's not approved for use in women. As a result, the American Medical Association (AMA) voted against giving ralox a drug approval. The FDA, however, still considered it a safe compound and approved ralox for use in women who have severe uterine bleeding. And, ralox (at least ralox) has proved effective when taken before and after pregnancy. In fact, a study done 2012 showed that ralox (at least ralox) stopped about 70% of all miscarriages. And, as far we know, ralox is still the only form of birth control approved for use in women. But, ralox still has some pretty serious critics. And, it's not just birth control. been shown to cause problems in pregnant women, too. For instance, in 2003, a group called Contraception Now published a study called "Ralox in the Absence of Risk" which looked at the safety of Viagra 30 Pills 50mg $55 - $1.83 Per pill ralox for women who didn't smoke and did not drink alcohol. According to the study, "The only significant finding from this study was that non-drinkers and non-smokers (non-drinkers included only those who did not consume alcohol) were at significantly increased risk of an abortion compared to abstainers." While those findings were pretty alarming, the problem with study was lack of controls. For starters, the study simply did not look for birth defects in the babies that were born to women who used ralox. The study also didn't compare ralox with other forms of birth control or even with hormonal contraception. In fact, the study didn't even try to see if the babies developed birth defects like spina bifida or cleft palate. The study authors did note that they had examined birth defects in a small group of women, but they couldn't rule out the possibility that birth defects were due to another substance in the pill that.

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